Virginia State Route 21 is a primary state highway located in the southwestern region of Virginia. It runs approximately 40 miles, connecting the towns of Bristol and Wytheville. The route primarily serves as a vital link for local traffic and provides access to various communities along its path. The highway is known for its scenic views, passing through rural landscapes and small towns. It intersects with several other major roads, enhancing connectivity in the area. Virginia State Route 21 plays an essential role in the transportation network, facilitating travel and commerce in the region.