U.S. Route 72 is a major east-west highway in the United States, stretching approximately 200 miles across the state of Alabama. It begins in the city of Memphis, Tennessee and ends in the town of Bridgeport, Alabama. The route serves as an important connector for various communities and facilitates travel across the region. Established in the 1920s, U.S. Route 72 has undergone several changes and improvements over the years. It passes through several cities, including Huntsville and Athens, providing access to local attractions and businesses. The highway is a vital part of the transportation network in northern Alabama.