U.S. Route 65 is a north-south highway that stretches approximately 1,578 miles across the central United States. It begins in the state of Louisiana and travels through several states, including Arkansas, Missouri, and Iowa, before ending in Minnesota. The route serves as a vital connector for various cities and rural areas along its path. Established in 1926, U.S. Route 65 is part of the U.S. Highway System, which was created to facilitate travel and commerce. The highway passes through diverse landscapes, including forests, rivers, and farmlands, making it an important route for both local and long-distance travelers.