U.S. Route 57 is a north-south highway in the United States, primarily located in the state of Missouri. It runs approximately 50 miles, connecting the towns of Poplar Bluff and Malden. The route serves as a vital link for local traffic and provides access to various communities along its path. Established in the mid-20th century, U.S. Route 57 is part of the larger U.S. highway system. It features a mix of rural landscapes and small towns, making it an important route for both residents and travelers exploring the region.