U.S. Route 25E is a north-south highway that runs through the eastern United States. It begins in Middlesboro, Kentucky and travels through Tennessee, eventually ending in Newport, Tennessee. The route serves as an important connector for local communities and travelers in the region. The highway spans approximately 140 miles and offers scenic views, particularly as it passes through the Appalachian Mountains. U.S. Route 25E is part of the larger U.S. Route 25, which extends from Florida to Michigan, but 25E is specifically designated for the eastern segment.