U.S. Route 150 is a highway in the United States that runs primarily through the states of Illinois and Indiana. It stretches approximately 150 miles, connecting various towns and cities, and serves as an important route for local traffic and commerce. The route begins in Hannibal, Missouri, and travels eastward, passing through notable locations such as Champaign and Bloomington in Illinois. It eventually reaches its eastern terminus in New Albany, Indiana, where it intersects with other major highways, facilitating travel across the region.