Two's Complement is a method for representing signed integers in binary form. It allows computers to perform arithmetic operations like addition and subtraction easily. In this system, the most significant bit (MSB) indicates the sign of the number: 0 for positive and 1 for negative. To find the two's complement of a binary number, you invert all bits and add 1 to the least significant bit (LSB). This representation simplifies calculations because it eliminates the need for separate circuits to handle positive and negative numbers. It is widely used in computer systems and programming languages, making it a fundamental concept in computer science and digital electronics.