Tumor Necrosis Factors (TNFs) are a group of proteins produced by the immune system that play a crucial role in inflammation and cell signaling. They help regulate immune responses, promote cell death, and inhibit tumor formation. The most well-known member of this family is TNF-alpha, which is involved in systemic inflammation and is a key player in autoimmune diseases. In addition to their role in immune responses, TNFs are also important in the development and progression of certain diseases, including cancer. They can influence tumor growth by either promoting or inhibiting it, depending on the context. Understanding TNFs is essential for developing targeted therapies for various inflammatory and cancerous conditions.