"The Tonight Show with Conan O'Brien" was a late-night talk show that aired on NBC from June 1, 2009, to January 22, 2010. Hosted by comedian Conan O'Brien, the show featured celebrity interviews, comedy sketches, and musical performances. O'Brien's unique style and humor brought a fresh perspective to the long-running franchise. The show was notable for its creative segments and O'Brien's signature self-deprecating humor. Despite a strong fan base, it faced challenges in ratings compared to its predecessor, The Tonight Show with Jay Leno. Ultimately, O'Brien left the show after a brief tenure, paving the way for The Tonight Show with Jimmy Fallon.