"The Pick of Destiny" is a musical comedy film released in 2006, featuring the rock duo Tenacious D, consisting of Jack Black and Kyle Gass. The story follows the characters JB and KG as they embark on a quest to find a magical guitar pick that grants its user extraordinary musical abilities. The film combines elements of fantasy and humor, showcasing various musical performances and comedic moments. It explores themes of friendship, ambition, and the power of music, ultimately culminating in a battle against the devil, portrayed by Dave Grohl, for rock supremacy.