"The Kathy and Mo Show" is a comedy performance created by actresses Kathy Najimy and Mo Gaffney. The show features a series of humorous sketches that explore various themes, including friendship, relationships, and everyday life experiences. It is known for its witty dialogue and relatable characters. The show originally premiered in the early 1990s and gained popularity for its unique blend of comedy and social commentary. It has been performed in various venues and has also been adapted for television, showcasing the talents of both Najimy and Gaffney as they engage audiences with their comedic chemistry.