"The Devil's Highway" refers to a treacherous stretch of desert in southern Arizona, known for its extreme heat and harsh conditions. This area is part of the larger Sonoran Desert and has become a dangerous route for many migrants attempting to cross the U.S.-Mexico border. The term gained prominence from the book "The Devil's Highway" by Luis Alberto Urrea, which recounts the harrowing journey of a group of migrants in 2001. The narrative highlights the risks they face, including dehydration and disorientation, as they navigate this perilous landscape in search of a better life.