Template Strings are a feature in programming languages like JavaScript that allow for easier string manipulation. They use backticks (``) instead of single or double quotes, enabling multi-line strings and the inclusion of expressions directly within the string. This makes it simpler to create dynamic content without needing to concatenate multiple strings. With Template Strings, you can embed variables and expressions using the `${}` syntax. For example, writing ``Hello, $name!`` will replace `$name` with the value of the variable `name`. This enhances readability and reduces errors in string formatting, making code cleaner and more maintainable.