Systemic mycoses are fungal infections that affect internal organs and can spread throughout the body. These infections are typically caused by specific fungi, such as Histoplasma capsulatum, Coccidioides immitis, and Blastomyces dermatitidis. They often enter the body through the lungs and can lead to serious health issues if not treated promptly. Diagnosis of systemic mycoses usually involves laboratory tests, imaging studies, and clinical evaluation. Treatment often includes antifungal medications, which can vary depending on the specific fungus involved. Early detection and appropriate therapy are crucial for improving patient outcomes and preventing complications.