A systemic infection occurs when pathogens, such as bacteria or viruses, spread throughout the body, affecting multiple organs or systems. Unlike localized infections, which are confined to one area, systemic infections can lead to severe health complications and may require immediate medical attention. Common examples include sepsis and bacteremia. Symptoms of a systemic infection often include fever, chills, fatigue, and confusion. Diagnosis typically involves blood tests and imaging studies to identify the source of the infection. Treatment usually consists of antibiotics or antiviral medications, depending on the type of pathogen involved, along with supportive care to manage symptoms.