Succinate Dehydrogenase is an enzyme found in the mitochondria of cells. It plays a crucial role in the Krebs cycle, which is essential for energy production. This enzyme catalyzes the conversion of succinate to fumarate, facilitating the transfer of electrons to the electron transport chain. In addition to its role in energy metabolism, Succinate Dehydrogenase is unique because it is the only enzyme that participates in both the Krebs cycle and the electron transport chain. Deficiencies or mutations in this enzyme can lead to various health issues, including certain types of cancer and mitochondrial diseases.