Sterics refers to the spatial arrangement of atoms in a molecule and how this arrangement affects its chemical behavior. It plays a crucial role in determining the reactivity, stability, and interactions of molecules. Understanding sterics helps chemists predict how different substances will react with one another. In organic chemistry, sterics is often discussed in relation to steric hindrance, which occurs when bulky groups around a reactive site impede reactions. This concept is essential for designing drugs and catalysts, as the size and shape of molecules can significantly influence their effectiveness and selectivity in various chemical processes.