State Route 16 (Ohio) is a major east-west highway that spans approximately 130 miles across the state. It begins in the city of Zanesville and travels through several counties, including Muskingum, Licking, and Knox, before ending in Mount Vernon. The route serves as an important connector for local communities and facilitates regional travel. Originally designated in the 1920s, State Route 16 has undergone various improvements and upgrades over the years. It features a mix of rural and urban landscapes, providing access to both residential areas and commercial districts. The highway is also part of the larger Ohio State Route system, which includes numerous other routes throughout the state.