State Road 21 is a significant highway located in the state of Florida. It runs primarily in a north-south direction, connecting various communities and providing access to key areas. The road serves as an important route for both local traffic and travelers exploring the region. The highway stretches approximately 30 miles, starting from Melrose in the south and extending to Keystone Heights in the north. Along its route, State Road 21 intersects with several other roads, facilitating easy access to nearby towns and attractions, making it a vital part of the local transportation network.