Spatialite is an extension of the SQLite database that adds support for spatial data. It allows users to store and manage geographic information, making it useful for applications that require mapping and location-based services. With Spatialite, users can perform complex spatial queries and analyses, such as finding distances between points or determining if a point lies within a specific area. This makes it a popular choice for developers working on geographic information systems (GIS) and other location-aware applications.