The Sodium-Chloride Cotransporter (NCC) is a protein found in the kidneys that helps regulate the balance of sodium and chloride ions in the body. It operates primarily in the distal convoluted tubule of the nephron, where it reabsorbs sodium and chloride from urine back into the bloodstream. This process is essential for maintaining fluid balance and blood pressure. NCC functions by using the sodium gradient created by the Sodium-Potassium Pump to transport sodium and chloride ions together into the cells. This cotransport mechanism is crucial for electrolyte homeostasis and is a target for certain diuretics, which help manage conditions like hypertension and edema.