Sezary syndrome is a rare type of blood cancer that affects the skin and is considered a form of cutaneous T-cell lymphoma. It is characterized by the presence of abnormal T-cells in the blood, which can lead to severe skin symptoms, including redness, itching, and scaling. Patients may also experience swollen lymph nodes and other systemic symptoms. Diagnosis typically involves a skin biopsy and blood tests to identify the abnormal T-cells. Treatment options may include chemotherapy, targeted therapy, and phototherapy, aimed at controlling symptoms and managing the disease. Early detection and intervention are crucial for improving outcomes.