Sesamoiditis is a condition that involves inflammation of the sesamoid bones, which are small bones located beneath the big toe joint. These bones help with the movement and function of the toe, and when they become irritated, it can lead to pain and discomfort, especially during activities like walking or running. The primary cause of sesamoiditis is often repetitive stress or overuse, commonly seen in athletes or individuals who engage in high-impact activities. Treatment typically includes rest, ice, and anti-inflammatory medications, and in some cases, custom orthotics may be recommended to alleviate pressure on the affected area.