Secondary immune deficiency occurs when the immune system is weakened due to external factors, rather than being inherited. This can result from various causes, including infections like HIV, certain medications such as chemotherapy, malnutrition, or chronic diseases like diabetes. As a result, the body becomes more susceptible to infections and illnesses. Unlike primary immune deficiency, which is present at birth, secondary immune deficiency can develop at any age. It is important to identify and treat the underlying cause to help restore immune function. Management may involve medications, lifestyle changes, or addressing nutritional deficiencies to improve overall health.