Schedule II refers to a classification of drugs in the United States that have a high potential for abuse but also have accepted medical uses. These substances can lead to severe psychological or physical dependence. Examples include medications like morphine, oxycodone, and amphetamine. Due to their potential for misuse, Schedule II drugs are strictly regulated. Prescriptions for these medications must be written by a licensed healthcare provider and cannot be refilled; patients need a new prescription for each supply. This regulation aims to ensure safe use while minimizing the risk of addiction.