"Samantha Who?" is a television sitcom that aired from 2007 to 2009. The show stars Christina Applegate as Samantha Newly, a woman who suffers from amnesia after an accident. As she tries to piece together her past, she discovers that she was not the person she thought she was, leading to comedic and heartfelt situations. The series explores themes of identity and personal growth, as Samantha navigates her relationships with her family and friends, including her best friend Dena and her love interest Todd. The show received positive reviews for its writing and performances, particularly Applegate's portrayal of the lead character.