Salazar Slytherin's locket is a magical artifact associated with one of the four founders of Hogwarts School of Witchcraft and Wizardry. It is a piece of jewelry that features a serpent, symbolizing Slytherin's affinity for snakes and his belief in blood purity. The locket is known to be one of the Hocruxes created by Lord Voldemort to achieve immortality, as it contains a fragment of his soul. The locket was stolen from Merope Gaunt, a descendant of Slytherin, and later came into the possession of Tom Riddle. It was eventually discovered by Harry Potter and his friends during their quest to defeat Voldemort. The locket is significant