"Rizzoli and Isles" is a crime drama television series based on the novels by Tess Gerritsen. The show premiered on TNT in 2010 and ran for seven seasons, concluding in 2016. It follows the partnership between Detective Jane Rizzoli, a tough Boston police officer, and Dr. Maura Isles, a brilliant medical examiner. Together, they solve complex murder cases while navigating their personal lives. The series is known for its blend of suspense, humor, and strong character development. Angie Harmon portrays Rizzoli, while Sasha Alexander plays Isles. The dynamic between the two leads highlights themes of friendship and resilience amidst the challenges of their demanding careers.