"Right Hand of Doom" is a significant element in the Hellboy comic series created by Mike Mignola. It refers to the powerful, stone-like hand of the main character, Hellboy, which is made from a mystical material called Anung Un Rama. This hand grants him immense strength and serves as a key to unlocking ancient powers. The hand is not only a source of Hellboy's abilities but also a symbol of his destiny. It connects him to dark forces and the potential for destruction, making it a central theme in his struggle between good and evil throughout the series.