The Renwick Smallpox Hospital, located on Roosevelt Island in New York City, was built in 1856 to treat patients suffering from smallpox. Designed by architect James Renwick Jr., the hospital featured a distinctive Gothic Revival style and was one of the first dedicated smallpox hospitals in the United States. It operated until the early 20th century, when the disease became less common due to vaccination efforts. After its closure, the building fell into disrepair and was eventually abandoned. Today, the ruins of the Renwick Smallpox Hospital are a historical landmark, serving as a reminder of the city's public health challenges and the fight against infectious diseases.