Receptor Guanylyl Cyclase (rGC) is an enzyme that plays a crucial role in cellular signaling. It is activated by binding to specific ligands, such as nitric oxide (NO) or natriuretic peptides. Once activated, rGC converts GTP (guanosine triphosphate) into cGMP (cyclic guanosine monophosphate), a secondary messenger that regulates various physiological processes, including smooth muscle relaxation and blood pressure control. cGMP produced by rGC influences several downstream signaling pathways, affecting functions like vascular tone and cell growth. Dysregulation of rGC or its signaling pathways can lead to various health issues, including cardiovascular diseases. Understanding rGC's role is essential for developing targeted therapies for these conditions.