RUNX2 is a gene that plays a crucial role in the development and function of bones. It encodes a protein that is essential for the formation of bone tissue and regulates the activity of other genes involved in bone growth and mineralization. Mutations in the RUNX2 gene can lead to skeletal disorders, such as cleidocranial dysostosis, which affects bone development. In addition to its role in bone formation, RUNX2 is also involved in the differentiation of certain types of cells, including osteoblasts, which are responsible for building bone. This gene is important for maintaining bone density and overall skeletal health, making it a key focus in research related to bone diseases and regenerative medicine.