Princess Isabel of Castile was born on April 22, 1451, in Madrigal de las Altas Torres, Spain. She was the daughter of John II of Castile and Isabella of Portugal. Isabel became a significant historical figure as she later married Ferdinand II of Aragon, uniting the crowns of Castile and Aragon, which laid the foundation for modern Spain. Isabel played a crucial role in the Spanish Inquisition and the exploration of the New World, supporting Christopher Columbus on his voyages. Her reign, alongside Ferdinand, is often marked by the completion of the Reconquista, culminating in the capture of Granada in 1492.