"Pineapple Express" is a 2008 comedy film that follows the misadventures of a stoner named Dale Denton, played by Seth Rogen, who witnesses a murder while delivering a subpoena. In a panic, he goes on the run with his dealer, Saul Silver, portrayed by James Franco. Their journey is filled with hilarious situations as they try to evade dangerous criminals and the police. The title refers to a rare strain of marijuana that Dale is smoking, which becomes a central element of the plot. As the duo navigates their chaotic escapades, they learn about friendship and loyalty, all while providing plenty of laughs.