Phosphoglycerate Kinase (PGK) is an enzyme that plays a crucial role in the process of glycolysis, which is the breakdown of glucose to produce energy. It catalyzes the conversion of 3-phosphoglycerate to 1,3-bisphosphoglycerate, using ATP as a phosphate donor. This reaction is essential for energy production in cells. PGK is found in various organisms, including bacteria, plants, and animals, highlighting its importance in cellular metabolism. The enzyme is highly conserved across species, indicating its fundamental role in energy metabolism. Deficiencies or malfunctions in PGK can lead to metabolic disorders, affecting overall health.