A Persistence Framework is a software library or set of tools that helps developers manage data storage and retrieval in applications. It simplifies the process of interacting with databases by providing a structured way to perform operations like creating, reading, updating, and deleting data. This allows developers to focus on application logic rather than the complexities of database management. Common examples of persistence frameworks include Hibernate for Java and Entity Framework for .NET. These frameworks often support various database systems and offer features like object-relational mapping (ORM), which helps translate data between the application and the database seamlessly.