The Panguipulli River is located in the Los Ríos Region of southern Chile. It flows from Lake Panguipulli and eventually merges with the Futrono River. The river is known for its scenic beauty, surrounded by lush forests and mountains, making it a popular spot for outdoor activities like fishing and kayaking. The river plays a significant role in the local ecosystem and supports various wildlife. It is also important for the communities nearby, providing water resources and recreational opportunities. The Panguipulli River is part of the larger Valdivian temperate rain forest biome, which is rich in biodiversity.