PLP1, or phospholipid scramblase 1, is a protein that plays a crucial role in the movement of phospholipids between the inner and outer leaflets of cell membranes. This process is important for various cellular functions, including blood coagulation and cell signaling. PLP1 is particularly significant during events like apoptosis, where it helps in the externalization of phosphatidylserine, a signal for macrophages to clear dying cells. Mutations in the PLP1 gene can lead to disorders such as Pelizaeus-Merzbacher disease, a rare genetic condition affecting the nervous system. This disease is characterized by the improper formation of myelin, the protective sheath around nerve fibers, leading to neurological symptoms. Understanding PLP1's function is essential for developing potential therapies for related conditions.