The P-2Y receptor is a type of G protein-coupled receptor that responds to nucleotides, such as ATP and ADP. It plays a crucial role in various physiological processes, including platelet activation, inflammation, and neurotransmission. There are several subtypes of P-2Y receptors, each with distinct functions and tissue distributions. Activation of P-2Y receptors can lead to various cellular responses, such as changes in ion channel activity and intracellular signaling pathways. These receptors are important in the cardiovascular system and the central nervous system, influencing blood flow and neuronal communication, respectively.