Organic acidurias are a group of metabolic disorders caused by the body's inability to break down certain organic acids. This can lead to a buildup of these acids in the blood and urine, which can cause various health issues. Symptoms may include vomiting, lethargy, and developmental delays, depending on the specific type of organic aciduria. These disorders are often diagnosed through newborn screening tests, which check for elevated levels of organic acids. Treatment typically involves dietary management and supplementation to help reduce acid levels and prevent complications. Early detection is crucial for improving outcomes in affected individuals.