An ORF, or Open Reading Frame, is a sequence of DNA or RNA that has the potential to be translated into a protein. It begins with a start codon, typically AUG, and ends with a stop codon, such as UAA, UAG, or UGA. ORFs are crucial for understanding the genetic code and identifying genes within a genome. In molecular biology, identifying ORFs helps researchers determine which parts of the genetic material are functional and can produce proteins. This information is essential for various applications, including genetic engineering, biotechnology, and medicine, as it aids in the study of gene expression and protein function.