The Nulato River is a tributary of the Yukon River located in central Alaska. It flows approximately 150 miles through the Yukon-Koyukuk Census Area, providing important access to remote communities and natural resources. The river is known for its scenic beauty and diverse wildlife, making it a vital habitat for various species. The Nulato River is significant for local Indigenous communities, including the Yup'ik and Koyukon peoples, who rely on its waters for fishing and transportation. The river's ecosystem supports salmon runs, which are crucial for both subsistence and cultural practices in the region.