Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs) are a class of medications that help increase the levels of two important neurotransmitters in the brain: norepinephrine and dopamine. By blocking the reabsorption (or reuptake) of these chemicals, NDRIs enhance their availability, which can improve mood and focus. They are often used to treat conditions like depression and attention deficit hyperactivity disorder (ADHD). One well-known NDRI is bupropion, which is commonly prescribed for depression and as a smoking cessation aid. Unlike some other antidepressants, NDRIs typically have fewer side effects related to weight gain and sexual dysfunction. This makes them a popular choice for many patients