A Non-Treponemal Test is a type of blood test used to screen for syphilis, a sexually transmitted infection caused by the bacterium Treponema pallidum. This test detects non-specific antibodies that the body produces in response to the infection, rather than targeting the bacteria directly. Common examples of non-treponemal tests include the Venereal Disease Research Laboratory (VDRL) test and the Rapid Plasma Reagin (RPR) test. These tests are often used for initial screening because they are quick and inexpensive. However, they can produce false-positive results due to other conditions, such as HIV or lupus. If a non-treponemal test is positive, a more specific test, known as a treponemal test, is usually performed to confirm the diagnosis of syphilis.