The New Madrid River is a significant waterway located in the southeastern region of Missouri, USA. It flows through the New Madrid County and is part of the larger Mississippi River watershed. The river is known for its historical importance, particularly during the early 19th century when it was a key transportation route for goods and people. The river is also notable for its role in the New Madrid Earthquakes of 1811-1812, which were some of the most powerful earthquakes in U.S. history. These seismic events altered the landscape and affected the river's course, making it an area of interest for both geologists and historians.