Neurokinin B is a neuropeptide that plays a crucial role in the regulation of various physiological processes, including pain perception, stress response, and reproductive functions. It is part of the tachykinin family of peptides and primarily acts on neurokinin-3 receptors in the brain and other tissues. This neuropeptide is particularly important in the hypothalamus, where it influences the release of gonadotropin-releasing hormone (GnRH), impacting reproductive hormone levels. Dysregulation of neurokinin B signaling has been linked to conditions such as hypogonadism and polycystic ovary syndrome (PCOS).