Neonatal Sepsis is a serious infection that occurs in newborns, typically within the first 28 days of life. It can be caused by bacteria, viruses, or fungi entering the bloodstream, leading to systemic illness. Symptoms may include fever, difficulty breathing, poor feeding, and lethargy. Early diagnosis and treatment are crucial for improving outcomes. The condition can be classified as either early-onset, occurring within the first 72 hours after birth, or late-onset, appearing after this period. Risk factors include premature birth, low birth weight, and maternal infections during pregnancy. Prompt medical attention is essential for affected infants.