Negishi coupling is a chemical reaction that allows for the formation of carbon-carbon bonds. It involves the coupling of an organozinc compound with an organic halide, typically in the presence of a palladium catalyst. This method is valued for its ability to create complex molecules efficiently and selectively. The reaction was developed by Akira Negishi, who received the Nobel Prize in Chemistry in 2010 for his contributions to the field of organic synthesis. Negishi coupling is widely used in the pharmaceutical and materials industries to synthesize various compounds, including drugs and polymers.