NOD-like receptors (NLRs) are a group of proteins that play a crucial role in the immune system. They are part of the body's defense mechanism, helping to detect pathogens like bacteria and viruses. When NLRs recognize these harmful invaders, they trigger an immune response to help eliminate the threat. These receptors are located in the cytoplasm of cells and can sense various danger signals, including damaged cellular components. By activating inflammatory pathways, NLRs contribute to the body's ability to respond to infections and maintain overall health, making them essential for proper immune function.