NOD-like receptors (NLRs) are a type of pattern recognition receptor found in the cytoplasm of cells. They play a crucial role in the immune system by detecting pathogens and cellular stress signals. When activated, NLRs initiate inflammatory responses and help regulate the body's defense mechanisms against infections. These receptors are part of the innate immune system and can recognize various molecular patterns associated with bacteria, viruses, and fungal infections. By triggering signaling pathways, NLRs contribute to the production of cytokines, which are essential for coordinating the immune response and maintaining homeostasis within the body.